办公地点

Room 409， Department of Regenerative Medical , Jilin University

办公电话

0431-85619718

邮箱

xu_hui@jlu.edu.cn

教育背景

1993-1998 Bachlor, Clinical Medicine, Inner Mongolia Medical University, Hohhot.

1998-2001 Master, Pathology, Jilin University, Jilin

2001-2004 Medical Doctor, Pathology, Jilin University, Jilin

工作经历

2011- Professor & doctoral supervisor, School of Pharmacitical Science, Jilin University

主讲课程

proteomics，Pharmacognosy and nutrition health care

研究领域

Osteoporosis, Skeletal fluorosis, Anti-osteoprorosis drug, Natural product

科研成果

Publications:

1. Effect of fluoride on osteocyte-driven osteoclastic differentiation. Toxicology. 2020 APR 30;436:152429.

2. The antiresoptive effects of recombinant Lingzhi-8 protein against retinoic acid-induced osteopenia. European J Pharmacology. 2019; 863; 172699

3. Different effects of fluoride exposure on the three major bone cell types. Biol Trace Elem Res. 2020 Jan, 193(1): 226-233

4. Requirement of TGFβ signaling for effect of fluoride on osteoblastic differentiation. Biol Trace Elem Res. 2019 Feb;187(2):492-498.

5. PTH (1-34) affects bone turnover governed by osteocytes exposed to fluoride. Toxicol Lett. 2018 May 15;288:25-34

6. The role of TGFβ receptor 1-smad3 signaling in regulating the osteoclastic mode affected by fluoride. Toxicology. 2018 Jan 15;393:73-82.

7. Fluoride Regulate Osteoblastic Transforming Growth Factor-beta 1 Signaling by Mediating Recycling of the Type I Receptor ALK5. PLoS One. 2017 Jan 26;12(1):e0170674. d

8. Preliminary Analysis of MicroRNAs expression profiling in MC3T3-E1 cells exposed to fluoride. Biol Trace Elem Res. 2017 Apr; 176(2):367-373. 2.399

9. Treatment and Prevention of Skeletal Fluorosis. Biomed Environ Sci. 2017; 30(2): 147-149.

10. Oxidative stress in mechanism underlying Streptozotocin aggravated dental fluorosis. Fluoride. 2016 (Jul-Sep), 49(3 Pt2): 327-335

11. Analysis of the role of insulin signaling in bone turnover induced by fluoride. Biol Trace Elem Res. 2016 Jun; 171(2):380-390.

12. Streptozotocin aggravated osteopathology and insulin induced osteogenesis through co-treatment with fluoride. Biol Trace Elem Res. 2015 Dec; 168(2):453-461. 1.798

13. Sun F, Li X, Yang C, Lv P, Li G, Xu Hui*. A role for PERK in the mechanism underlying fluoride-induced bone turnover. Toxicology. 2014 Nov; 325:52-66. 3.621

14. Lü P, Li X, Ruan L, Xu Hui, Liu Q*. Effect of siRNA PERK on fluoride-induced osteoblastic differentiation in OS732 cells. Biol Trace Elem Res. 2014 Jun; 159(1-3):434-439.

15. Role of PTH on fluoride-affected osteoclastic differentiation induced by co-culture with osteocytes. Report on the xxxivth conference of the International Society of Fluoride Research. 2018, 10.18-10.20

Books:

1. Experimental Diagnosis of Bone Metabolism. Chemical Industry Press Co., Ltd. Jan 2020

2. Endemic Fluorosis Caused by Coal-buring. 2015年12月， People’s Medical Publishing House Co., Ltd. Dec 2015.