Address

Room 501, School of Pharmacitical Science

Tle.

13904331190

Email

liuzy@jlu.edu.cn

Education Background

1981-1985 Bachlor,College of Chemistry, Jilin University

1987-1990 Master, Biochemistry, Norman Bethune University of Medical Science

2001-2005 Ph.D. , Analytical chemistry，College of Chemistry,Jilin University

Work Experience

2004- Professor & doctoral supervisor, School of Pharmacitical Science, Jilin University

1998-2004 Vice Professor & master supervisor, School of Pharmacitical Science, Jilin University

1985-1998，Lecturer, Norman Bethune University of Medical Science

Courses

Pharmaceutical Analysis；Biopharmaceutical Analysis

Research Field

Advanced Pharmaceutical Analysis；Pharmacodynamic material basis

Scientific Research Achievements

Publications:

1. Fu, J., Li, J.X., Sun, Y.Z., Liu, S., Song, F.R., Liu, Z.Y.*, (2023). In-depth investigation of the mechanisms of Schisandra chinensis polysaccharide mitigating Alzheimer's disease rat via gut microbiota and feces metabolomics. Int J Biol Macromol, 232, p123488.

2. Wang, M.Y., Li, H.L., Gao, Y., Li, Y.Y., Sun, Y.Z., Liu, S., Liu, Z.Y.*, (2022). A multidimensional strategy to rapidly identify the chemical constituents in Shengxian Decoction by using ultra-performance liquid chromatography coupled with ion mobility spectrometry quadrupole time-of-flight mass spectrometry. J Sep Sci, 450(16), p3115-3127.

3. Yue, K.X., Liu, Z.Q., Pi, Z.F., Li, H.L., Wang, Y.P., Song, F.R., Liu, Z.Y.*, (2022). Network Pharmacology Combined with Metabolomics Approach to Investigate the Toxicity Mechanism of Paclobutrazol. Chem Res Toxicol, 35(4), p626-635.

4. Yue, K.X., Li, H.L., Pi, Z.F., Song, F.R., Wang, Y.P., Liu, Z.Y.*, (2022). Multiresidue screening of pesticides in Panax Ginseng C. A. Meyer by ultra-high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. J Sep Sci, 45(10), p1702-1710.

5. Wang, X.S., Hu, M.X., Guan, Q.X., Men, L.H., Liu, Z.Y.*, (2022). Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats. Chin J Nat Med, 20(5), p378-386.

6. Fu, J., Zhang, H.X., Liu, S., Wu, J.J., Zhang, Y.Y., Gao, Y., Song, F.R., Qin, Y.H., Hu, X.L., Liu, Z.Y.*, ((2021)). An integrated strategy using LC-MS/MS combined with in vivo microdialysis for the simultaneous determination of lignans of Schisandra chinensis (Turcz.) Baill. Fructus and endogenous neurotransmitters, papplication in pharmacokinetic and pharmacodynamic studies. Food Funct, 12(19), p8932-8945.

7. Zhou, Y., Wei, M.Y., Fan, M.L., Liu, Z.Y.*, Wang, A.M., Liu, Y.Y., Men, L.H., Pi, Z.F., Liu, Z.Q., Song, F.R., (2021). Pharmacokinetic and metabolomics approach based on UHPLC-MS to evaluate therapeutic effect of lignans from S. Chinensis in alzheimer's disease. J Chromatogr B Analyt Technol Biomed Life Sci, 1178, p122859.

8. Gao, Y., Wu, Y., Liu, S., Liu, Z.Q., Song, F.R., Liu, Z.Y.*, (2021). A strategy to comprehensively and quickly identify the chemical constituents in Platycodi Radix by ultra-performance liquid chromatography coupled with traveling wave ion mobility quadrupole time-of-flight mass spectrometry. J Sep Sci, 44(3), p691-708.

9. Men, L.H., Pi, Z.F., Hu, M.X., Liu, S., Liu, Z.Q., Song, F.R., Chen, X., Liu, Z.Y.*, (2021). Serum Metabolomics Coupled with Network Pharmacology Strategy to Explore Therapeutic Effects of Scutellaria Baicalensis Georgi on Diabetic Nephropathy. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 49(1), p21001-21013.

10. Gao, Y., Wu, Y., Liu, Z.Q., Fu, J., Zhang, Y.Y., Wu, J.J., Liu, S., Song, F.R., Liu, Z.Y.*, (2021). Based on urine metabolomics to study the mechanism of Qi-deficiency affecting type 2 diabetes rats using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 1179, p122850.

11. Wang, R.J., Liu, S., Liu, T.S., Wu, J.J., Zhang, H.X., Sun, Z.H., Liu, Z.Y.*, (2021). Mass spectrometry-based serum lipidomics strategy to explore the mechanism of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves in the treatment of ischemic stroke. Food Funct, 12(10), p4519-4534.

12. Shi, L.Q., Wang, R.J., Liu, T.S., Wu, J.J., Zhang, H.X., Liu, Z.Q., Liu, S., Liu, Z.Y.*, (2020). A rapid protocol to distinguish between Citri Exocarpium Rubrum and Citri Reticulatae Pericarpium based on the characteristic fingerprint and UHPLC-Q-TOF MS methods. Food Funct, 11(4), p3719-3729.

13. Wang, Y., Liu, S., Wang, R.J., Shi, L.Q., Liu, Z.Q., Liu, Z.Y.*, (2020). Study on the therapeutic material basis and effect of Acanthopanax senticosus (Rupr. et Maxim.) Harms leaves in the treatment of ischemic stroke by PK-PD analysis based on online microdialysis-LC-MS/MS method. Food Funct, 11(3), p2005-2016.

14. Wang, R.J., Shi, L.Q., Liu, S., Liu, Z.Q., Song, F.R., Sun, Z.H., Liu, Z.Y.*, (2019). Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats. J Ethnopharmacol, 241, p111969.

15. Wei, M.Y., Liu, Y.Y., Pi, Z.F., Yue, K.X., Li, S.Z., Hu, M.X., Liu, Z.Q., Song, F.R., Liu, Z.Y.*, (2019). Investigation of plasma metabolomics and neurotransmitter dysfunction in the process of Alzheimer's disease rat induced by amyloid beta 25-35. RSC Adv, 9(32), p18308-18319.

16. Wei, M.Y., Liu, Y.Y., Pi, Z.F., Li, S.Z., Hu, M.X., He, Y., Yue, K.X., Liu, T.S., Liu, Z.Q., Song, F.R., Liu, Z.Y.*, (2019). Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC⁻Q-TOF-MS. Molecules, 24(7).

17. Liu, Y.Y, Wei, M.Y., Yue, K.X., Wang, R.J., Ma, Y.H., Men, L.H., Pi, Z.F., Liu, Z.Q., Liu, Z.Y.*, (2019). Non-target metabonomic method provided new insights on the therapeutical mechanism of Gancao Fuzi decoction on rheumatoid arthritis rats. J Chromatogr B Analyt Technol Biomed Life Sci, 1105, p93-103.

18. MA, Y.H., LIU, Z.Y.*, WEI, M.Y., TSAO, R., (2019). Study on intestinal transport of the glycyrrhizic acid in the Gancaofuzi decoction across the Caco-2 cell monolayer model by HPLC-ESI-MS method. Acta Medica Mediterranea, 35, p3449-3455.

19. Liu, Y.Y., Wei, M.Y., Yue, K.X., Hu, M.X., Li, S.Z., Men, L.H., Pi, Z.F., Liu, Z.Q., Liu, Z.Y.*. (2018). Study on Urine Metabolic Profile of Aβ25-35-Induced Alzheimer's Disease Using UHPLC-Q-TOF-MS. Neuroscience, 394, p30-43.

20. Jiang, W.Y., Si, L.H., Li, P.D., Bai, B., Qu, J.L., Hou, B., Zou, H., Fan, X., Liu, Z.Q., Liu, Z.Y.*, (2018). Gao L.Serum metabonomics study on antidiabetic effects of fenugreek flavonoids in streptozotocin-induced rats. J Chromatogr B Analyt Technol Biomed Life Sci, 1092, p466-472.

21. Wei, M.Y., Ma, Y.H., Liu, Y.Y., Zhou, Y., Men, L.H., Yue, K.X., Pi, Z.F., Liu, Z.Q., Liu, Z.Y.*, (2018). Urinary metabolomics study on the anti-inflammation effects of flavonoids obtained from Glycyrrhiza. J Chromatogr B Analyt Technol Biomed Life Sci, 1086, p1-10.

22. Chen, W.J., Wu, Y., Bi, R.B., Liu, S., Y, Liu, Z.Y.*, Liu, Z.Q., Song, F.R., Shi, Y., (2017). Therapeutic Effects of Selaginella tamariscina on the Model of Acute Gout with Hyperuricemia in Rats Based on Metabolomics Analysis. CHINESE JOURNAL OF CHEMISTRY, 35(7), p1117-1124.

23. Jiang, W.Y., Gao, L., Li, P.D., Kan, H., Qu, J.L., Men, L.H., Liu, Z.Q., Liu, Z.Y.*, (2017). Metabonomics study of the therapeutic mechanism of fenugreek galactomannan on diabetic hyperglycemia in rats, by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 1044-1045, p8-16.

24. Men, L.H., Pi, Z.F., Zhou, Y., Wei, M.Y., Liu, Y.Y., Song, F.R., Liu, Z.Y.*, (2017). Urine metabolomics of high-fat diet induced obesity using UHPLC-Q-TOF-MS. J Pharm Biomed Anal, 132, p258-266.

25. Men, L.H., Pi, Z.F., Zhou, Y., Liu, Y.Y., Wei, M.Y., Song, F.R., Liu, Z.Y.*, (2017). Metabolomics insights into diabetes nephropathy and protective effects of Radix Scutellariae on rats using ultra-high performance liquid chromatography coupled with quadrupole time-of- flight mass spectrometry. RSC ADVANCES, 7(27), p16494-16504.

26. Chen, W.J., Wu, Y., Zhao, X., Liu, S., Song, F.R., Liu, Z.Q., Liu, Z.Y.*, (2016). Q.Screening the anti-gout traditional herbs from TCM using an in vitro method. CHINESE CHEMICAL LETTERS, 27(11), p1701-1707.

27. Ding, R., Jian, Y., Kan, H., Liu, Z.Y.*, Liu, S., Liu, Z.Q., Zhou, J., (2016). Studies on the intestinal absorption of the alkaloids in the Gancaofuzi decoction in a Caco-2 cell culture system by UPLC-MS/MS analysis. CHINESE CHEMICAL LETTERS, 27(6), p915-919.

28. Lin, H., Pi, Z.F., Men, L.H., Chen, W.J., Liu, Z.Q., Liu, Z.Y.*, (2016). Urinary metabonomic study of Panax ginseng in deficiency of vital energy rat using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.J Ethnopharmacol, 184, p10-7.

29. Ma, Y.H., Wei, M.Y., Liu, Y.Y., Song, F.R., Liu, Z.Y.*, Pi, Z.F., (2016). Study on intestinal transport of Veratrum alkaloids compatible with Panax ginseng across the Caco-2 cell monolayer model by UPLC-ESI-MS method. CHINESE CHEMICAL LETTERS, 27(2), p215-220.

30. Wang, J.Q., Jiang, W.Y., Zhang, L., Wang, J.H., Zhao, X., Wang, Y., Liu, Z.Y.*, (2016), Hypoglycemic effects of saponins, flavonoids, and polysaccharides of fenugreek with different component compatibilities on type 1 diabetic rats. Journal of Jilin Univeristy Medicine edition, 42(6), p1081-1086.