Scientific Research Achievements |
Publications: 1.JIN, Z., YU, N., BAI, J., LIU, Z., LI, H., ZHANG, J. & LIANG, C. 2022. Cross-amplified Barcodes on Slides for Spatial Transcriptomics Sequencing. bioRxiv, 2022.08.25.504658. 2.CONG, L., TIAN, Y., HUO, Z., XU, W., HOU, C., SHI, W., WANG, W., LIANG, C. & XU, S. 2022. Single-Cell VEGF Analysis by Fluorescence Imaging-Microfluidic Droplet Platform: An Immunosandwich Strategy on the Cell Surface. Anal Chem, 94, 6591-6598. 3.SUN, W., GUO, W., LIU, Z., QIAO, S., WANG, Z., WANG, J., QU, L., SHAN, L., SUN, F., XU, S., BAI, O. & LIANG, C. 2022. Direct MYD88(L265P) gene detection for diffuse large B-cell lymphoma (DLBCL) via a miniaturised CRISPR/dCas9-based sensing chip. Lab Chip, 22, 768-776. 4.SUN, D., XU, W., LIANG, C., SHI, W. & XU, S. 2020. Smart Surface-Enhanced Resonance Raman Scattering Nanoprobe for Monitoring Cellular Alkaline Phosphatase Activity during Osteogenic Differentiation. ACS Sens, 5, 1758-1767. 5.SHEN, Y., LIANG, L., ZHANG, S., HUANG, D., ZHANG, J., XU, S., LIANG, C. & XU, W. 2018. Organelle-targeting surface-enhanced Raman scattering (SERS) nanosensors for subcellular pH sensing. Nanoscale, 10, 1622-1630. 6.SHEN, Y., LIANG, L., ZHANG, S., HUANG, D., DENG, R., ZHANG, J., QU, H., XU, S., LIANG, C. & XU, W. 2018a. Organelle-Targeting Gold Nanorods for Macromolecular Profiling of Subcellular Organelles and Enhanced Cancer Cell Killing. ACS Appl Mater Interfaces, 10, 7910-7918. 7.LIANG, L., QU, H., ZHANG, B., ZHANG, J., DENG, R., SHEN, Y., XU, S., LIANG, C. & XU, W. 2017. Tracing sialoglycans on cell membrane via surface-enhanced Raman scattering spectroscopy with a phenylboronic acid-based nanosensor in molecular recognition. Biosens Bioelectron, 94, 148-154. 8.DENG, R., QU, H., LIANG, L., ZHANG, J., ZHANG, B., HUANG, D., XU, S., LIANG, C. & XU, W. 2017. Tracing the Therapeutic Process of Targeted Aptamer/Drug Conjugate on Cancer Cells by Surface-Enhanced Raman Scattering Spectroscopy. Anal Chem, 89, 2844-2851. 9.LIANG, L., HUANG, D., WANG, H., LI, H., XU, S., CHANG, Y., LI, H., YANG, Y. W., LIANG, C. & XU, W. 2015. In situ surface-enhanced Raman scattering spectroscopy exploring molecular changes of drug-treated cancer cell nucleus. Anal Chem, 87, 2504-10. patents for inventions: 1.A method of microarraying for tissue samples - 202210784857.1 2.A microdot matrix chip and its preparation method and application - 202111251159.7 3.A method for surface-enhanced Raman spectroscopy detection of genes based on CRISPR/Cas12a protein - 202111038379.1 4.A high-resolution spatial-omics detection method for tissue samples - 202110899807.3 5.A method for screening and angling natural drug products - 202110796203.6 6.A method for angling active small molecules from a library of mixed combinatorial chemical molecules - 202110765591.1 7.A DNA-encoded compound library drug molecule draping method - 202110686776.3 8.A SERS detection device - 202121311757.4 9.A method for rapid detection of loop-mediated isothermal amplification of nucleic acid products using a magnetic bead probe - 202110302845.6 10.A high-throughput screening method for targeted drugs - 202110238982.8 11.A method for identifying membrane receptor proteins of cells and a method for validating them - 202110101699.0 12.A peptide for detecting the specificity of bladder cancer antigen protein and its application - 202011420894.1 13.A Raman homogeneous detection method using antibody recognition of bound antigen - 202010917445.1 14.A porous anodic alumina-Cas/dCas family protein composite sensing membrane and its preparation method and application method - 202010713463.8 15.A novel recombinant anti-epidermal growth factor receptor monoclonal antibody and its application - 202010084356.3 16.Monoclonal antibody preparation method based on Raman spectroscopy and microdroplet technology - 201811650388.4 17.Recombinant Ganoderma immunomodulatory protein mutant and its application - 201710226093.3 |
