Address

Room 305, School of Pharmacy

Tel.

0431-85619702

E-mail

renlq@jlu.edu.cn

Education Background

1980-1985 Bachlor, Norman Bethune University of Medical Science

1985-1988 Master, Norman Bethune University of Medical Science

1993-1996 Ph.D., Norman Bethune University of Medical Science

Work Experience

2004- Professor/Doctoral Supervisor, School of Pharmacy, Jilin University

2002-2003 Postdoctoral fellow, Laval University, Canada

1999-2004 Associate Professor/Master Supervisor, School of Pharmacy, Jilin University

1997-1998 Foreigner Researcher, Aichi medical university, Japan

1988-1993 Pathologist, 2nd Hospital attached to Dalian Medical University

Courses

Drug toxicology, Replication of animal models for human diseases

Research Field

Cardiovascular and tumor pharmacology

Scientific Research Achievements

Publications:

1. ZHANG, Y., MA, J., LIU, S., CHEN, C., LI, Q., QIN, M. & REN, L. 2023. Ginsenoside F1 attenuates pirarubicin-induced cardiotoxicity by modulating Nrf2 and AKT/Bcl-2 signaling pathways. J Ginseng Res, 47(1), 106-116.

2. MA, J., WANG, F., CHEN, C., JI, J., HUANG, P., WEI, D., ZHANG, Y. & REN, L. 2023. Identification of prognostic genes signature and construction of ceRNA network in pirarubicin treatment of triple-negative breast cancer. Breast Cancer.

3. HUANG, P., WANG, F., ZHANG, Y., ZHANG, Y., QIN, M., JI, J., WEI, D. & REN, L. 2023. Icariin alleviates atherosclerosis by regulating the miR-205-5p/ERBB4/AKT signaling pathway. Int Immunopharmacol, 114, 109611.

4. ZHANG, Y., LIU, S., MA, J. L., CHEN, C., HUANG, P., JI, J. H., WU, D. & REN, L. 2022. Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway. Phytomedicine, 94, 153815.

5. MA, J., CHEN, C., LIU, S., JI, J., WU, D., HUANG, P., WEI, D., FAN, Z. & REN, L. 2022. Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis. Cancer Gene Ther, 29(11), 1578-1589.

6. HUANG, P., ZHANG, Y., WANG, F., QIN, M. & REN, L. 2022. MiRNA-205-5p regulates the ERBB4/AKT signaling pathway to inhibit the proliferation and migration of HAVSMCs induced by ox-LDL. Pathol Res Pract, 233, 153858.

7. ZHANG, Y., XU, D., HUANG, P., ZHANG, Y., LI, Q., FAN, Z. & REN, L. 2021a. Essential role of protein kinase C βI in icariin-mediated protection against atherosclerosis. J Pharm Pharmacol, 73(9), 1169-1179.

8. ZHANG, Y., LI, Q., XU, D., LI, T., GU, Z., HUANG, P. & REN, L. 2021b. Idarubicin-induced oxidative stress and apoptosis in cardiomyocytes: An in vitro molecular approach. Hum Exp Toxicol, 40(12), S553-s562.

9. WANG, S., LIU, H., ZHANG, Y. & REN, L. 2021. Efficacy of Alkaloids in Alleviating Myocardial Ischemia-Reperfusion Injury in Rats: A Meta-Analysis of Animal Studies. Biomed Res Int, 2021, 6661526.

10. QIN, M., LI, Q., WANG, Y., LI, T., GU, Z., HUANG, P. & REN, L. 2021. Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway. J Biochem Mol Toxicol, 35(1), e22615.

11. LOU, X., WANG, D., GU, Z., LI, T. & REN, L. 2021. Mechanism of microRNA regulating the progress of atherosclerosis in apoE-deficient mice. Bioengineered, 12(2), 10994-11006.

12. LIU, S., XU, D. S., MA, J. L., HUANG, P., WU, D. & REN, L. 2021a. LncRNA H19 Mitigates Oxidized Low-Density Lipoprotein Induced Pyroptosis via Caspase-1 in Raw 264.7 Cells. Inflammation, 44(6), 2407-2418.

13. LIU, S., XU, D. S., LI, M., ZHANG, Y., LI, Q., LI, T. T. & REN, L. 2021b. Icariin attenuates endothelial-mesenchymal transition via H19/miR-148b-3p/ELF5 in ox-LDL-stimulated HUVECs. Mol Ther Nucleic Acids, 23, 464-475.

14. LI, Q., XU, D., GU, Z., LI, T., HUANG, P. & REN, L. 2021. Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA-129-1-3p-mediated calcium signaling pathway. J Biochem Mol Toxicol, 35(7), e22794.

15. REN, L., LI, Q. & ZHANG, Y. 2020. Luteolin Suppresses the Proliferation of Gastric Cancer Cells and Acts in Synergy with Oxaliplatin. Biomed Res Int, 2020, 9396512.

16. LI, Q., QIN, M., TAN, Q., LI, T., GU, Z., HUANG, P. & REN, L. 2020a. MicroRNA-129-1-3p protects cardiomyocytes from pirarubicin-induced apoptosis by down-regulating the GRIN2D-mediated Ca(2+) signalling pathway. J Cell Mol Med, 24(3), 2260-2271.

17. LI, Q., QIN, M., LI, T., GU, Z., TAN, Q., HUANG, P. & REN, L. 2020b. Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway. Mol Cell Biochem, 466(1-2), 139-148.

18. ZHANG, Y., XU, R., LI, X., TAN, Q., HUANG, P., ZHANG, Y., QIN, M. & REN, L. 2019a. Effects of icariin on long noncoding RNA and mRNA expression profile in the aortas of apoE-deficient mice. Biosci Rep, 39(7):BSR20190855.

19. ZHANG, Y., MA, X. Y., ZHANG, T., QIN, M., SUN, B., LI, Q., HU, D. W. & REN, L. 2019b. Protective Effects of Apocynum venetum Against Pirarubicin-Induced Cardiotoxicity. Am J Chin Med, 47(5), 1075-1097.

20. ZHANG, Y., JIANG, X. & REN, L. 2019c. Optimization of the adipose-derived mesenchymal stem cell delivery time for radiation-induced lung fibrosis treatment in rats. Sci Rep, 9(1), 5589.

21. LOU, X., MA, X., WANG, D., LI, X., SUN, B., ZHANG, T., QIN, M. & REN, L. 2019. Systematic analysis of long non-coding RNA and mRNA expression changes in ApoE-deficient mice during atherosclerosis. Mol Cell Biochem, 462(1-2), 61-73.

Book:

1. LI, C. & REN, L. 2017. Replication of animal models for human diseases. China: People's Medical Publishing House.

Patents for invention:

1. REN, L. 2016. The invention relates to an antitumor drug composition containing total flavonoids from Apocynum leaves.