. 发表论文 [1] LIANG Chong-Yang, XU Wei-Qing, CAO Yan-Xin, LIU Li-Xia, ZHANG Shu-Qin, LIU Zhi-Yi, LI Hong-Rui, LI Bai-Zhi, SUN Fei. Dynamic Observation of Cellular Localization of Fluorescein Isothiocyanate Labeled Recombinant Ganoderma Lucidum Immunoregulatory Protein(rLz-8) in NB4 APL Cell[J]. Chemical Journal of Chinese Universities, 2009, 30(3):489-492. 2009 Mar [2] Chongyang Liang, Shuqin Zhang, Zhiyi Liu, Fei Sun. Ganoderma lucidum immunomodulatory protein(Lz-8) expressed in Pichia pastoris and the identification of immunocompetence. Sheng Wu Gong Cheng Xue Bao. 2009;25(3):441-447. 2009 Mar [3] ZHANG Shu-qin, LIU Zhi-yi, ZHANG Fu-ming, SUN Fei. Preparation of arbidol hydrochloride multi-layers controlled-released and evaluation of its release rate in vivo and in vitro[J]. Journal of Jilin University Medicine Edition, 2009, 35(4):758-761. 2009 Apr [4] Liang Huang, Fei Sun, Chongyang Liang, Yong-Xing He, Rui Bao, Lixia Liu, Cong-Zhao Zhou. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium. Proteins. 2009;75(2):524-527. doi:10.1002/prot.22346 2009 May 1 [5] Xumei Wang, Shuping Xu, Chongyang Liang, Hongrui Li, Fei Sun, Weiqing Xu. Enriching PMMA nanospheres with adjustable charges as novel templates for multicolored dye@PMMA nanocomposites. Nanotechnology. 2011;22(27):275608. doi:10.1088/0957-4484/22/27/275608 2011 Jul 8 [6] Chongyang Liang, Hongrui Li, Hui Zhou, Shuqin Zhang, Zhiyi Liu, Qiuli Zhou, Fei Sun. Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells. Oncol Rep. 2012;27(4):1079-1089. doi:10.3892/or.2011.1593 2012 Apr [7] Yuequn Cao, Chongyang Liang, Yong Zhang, Jianlin Lin, Fei Sun. New purification process of fungal immunomodulatory protein, FIP-fve from Flammulina velutipes via filtration and column chromatography[J]. African Journal of Biotechnology, 2013, 12(5):512-519. 2013 [8] Xiping Zhang, Fei Sun, Zhiyi Liu, Shuqin Zhang, Chongyang Liang. Recombinant Ganoderma lucidum immunomodulatory protein modified with polyethylene glycol. Mol Med Rep. 2013;7(3):975-980. doi:10.3892/mmr.2013.1281 2013 Mar [9] Hui Zhou, Fei Sun, Hongrui Li, Shuqin Zhang, Zhiyi Liu, Jin Pei, Chongyang Liang. Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. Immunopharmacol Immunotoxicol. 2013;35(3):426-433. doi:10.3109/08923973.2013.791834 2013 Jun [10] Xilin Sun, Wei Huang, Sijia Xiao, Chongyang Liang, Shuqin Zhang, Zhiyi Liu, Fei Sun. Extracellular expression and efficient purification of a functional recombinant Volvariella volvacea immunomodulatory protein (FIP-vvo) using Pichia pastoris system. Protein Expr Purif. 2014;94:95-100. doi:10.1016/j.pep.2013.10.022 2014 Feb [11] HOU Yue; SUN Fei; JIN Jing; LIU Zhiyi; ZHENG Qingchuan; LIANG Chongyang. Expression and Molecular Dynamics of Recombinant Ganoderma Lucidum Immunoregulatory Protein-IgG Fc(LZ8-Fc) Fusion Protein in Pichia pastoris[J]. 高等学校化学学报, 2014, 35(2):303-308. 2014 Feb [12] Wei Wei, Haoran Guo, Jingliang Li, Sangsang Ren, Zhenhong Wei, Wanguo Bao, Xiaoming Hu, Ke Zhao, Wenyan Zhang, Yulai Zhou, Fei Sun, Richard Markham, Xiao-Fang Yu. Circulating HFMD-associated coxsackievirus A16 is genetically and phenotypically distinct from the prototype CV-A16. PLoS One. 2014;9(4):e94746. Published 2014 Apr 15. doi:10.1371/journal.pone.0094746 2014 Apr 15 [13] He Guo, Fei Sun, Wei Huang, Zhiyi Liu, Shuqin Zhang, Qiuli Zhou, Chongyang Liang. The effect of rhG-CSF on spleen transcriptome in mouse leukopenia model induced by cyclophosphamide. Immunopharmacol Immunotoxicol. 2014;36(2):114-123. doi:10.3109/08923973.2013.869696 2014 Apr [14] Minghe Li, Zhihong Li, Chongyang Liang, Chengmin Han, Wei Huang, Fei Sun. Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2014;32(5):2183-2190. doi:10.3892/or.2014.3423 2014 Nov [15] Fei Sun, Xining Li, Chen Yang, PengLv, Guangsheng Li, HuiXu. A role for PERK in the mechanism underlying fluoride-induced bone turnover. Toxicology. 2014;325:52-66. doi:10.1016/j.tox.2014.07.006 2014 November [16] Minghe Li, Zhihong Li Jia Li, Liou Jin, Chengxue Jin, Chengmin Han, Xin Ji, Fei Sun. Enhanced antitumor effect of cisplatin in human oral squamous cell carcinoma cells by tumor suppressor GRIM‑19. Mol Med Rep. 2015;12(6):8185-8192. doi:10.3892/mmr.2015.4423 2015 Dec [17] Gefu Chi, Weiting Zhong, Yan Liu, Gejin Lu, Hongming Lü, Dacheng Wang, Fei Sun. Isorhamnetin protects mice from lipopolysaccharide-induced acute lung injury via the inhibition of inflammatory responses. Inflamm Res. 2016;65(1):33-41. doi:10.1007/s00011-015-0887-9 2016 Jan [18] Biao Zhang, Baizhi Li, Dai Chen, Jie Zong, Fei Sun, Huixin Qu , Chongyang Liang. Transcriptional Regulation of Aerobic Metabolism in Pichia pastoris Fermentation. PLoS One. 2016;11(8):e0161502. Published 2016 Aug 18. doi:10.1371/journal.pone.0161502 2016 Aug 18 [19] Lu Dai, Weikang Li, Fei Sun, Baizhi Li, Hongrui Li, Hongxing Zhang, Qingchuan Zheng, Chongyang Liang. A strategy of designing the ligand of antibody affinity chromatography based on molecular dynamics simulation. J Chromatogr A. 2016;1463:81-89. doi:10.1016/j.chroma.2016.08.004 2016 Sep 9 [20] Jing Jin, Yanting Shen, Biao Zhang, Rong Deng, Dianshuai Huang, Tianqi Lu, Fei Sun, Shuping Xu, Chongyang Liang. In situ exploration of characteristics of macropinocytosis and size range of internalized substances in cells by 3D-structured illumination microscopy. Int J Nanomedicine. 2018;13:5321-5333. Published 2018 Sep 12. doi:10.2147/IJN.S171973 2018 Sep 12 [21] Jing Jin, Yilong Zhu, Fei Sun, Zhifei Chen, Shuang Chen, Yiquan Li, Wenjie Li, Min Li, Chuanxin Cui, Yingli Cui, Xunzhi Yin, Shanzhi Li, Jin Zhao, Guo Yan , Xiao Li, Ningyi Jin. Synergistic antitumor effect of the combination of a dual cancer-specific oncolytic adenovirus and cisplatin on lung cancer cells. Oncol Lett. 2018;16(5):6275-6282. doi:10.3892/ol.2018.9470 2018 Nov [22] Huan Tang, Jinglin Chen, Lin Wang, Qianwen Li, Yue Yang, Zhe Lv , Han Bao , Yao Li , Xue Luan, Yan Li , Zhihui Ren , Xiaowei Zhou , Dengli Cong , Zhiyi Liu , Juan Jia , Hongyu Chen, Weitao Zhao , Qin Meng , Fei Sun, Jin Pei. Co-delivery of epirubicin and paclitaxel using an estrone-targeted PEGylated liposomal nanoparticle for breast cancer. Int J Pharm. 2020;573:118806. doi:10.1016/j.ijpharm.2019.118806 2020 Jan 5 [23] Han B, Yang Y, Chen J, Tang H, Sun Y, Zhang Z, Wang Z, Li Y, Li Y, Luan X, Li Q, Ren Z, Zhou X, Cong D, Liu Z, Meng Q, Sun F, Pei J. Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity. Int J Nanomedicine. 2020;15:553-571. Published 2020 Jan 24. doi:10.2147/IJN.S228715 2020 Jan 24 [24] Dianshuai Huang, Qingjie Fan, Zhiyi Liu, Shuqin Zhang, Wei Huang, Hongrui Li, Chongyang Liang, Fei Sun. An Epitope on EGFR Loading Catastrophic Internalization Serve as a Novel Oncotarget for Hepatocellular Carcinoma Therapy. Cancers (Basel). 2020;12(2):456. Published 2020 Feb 16. doi:10.3390/cancers12020456 2020 Feb 16 [25] Dianshuai Huang, Tianqi Lu, Xingyu Du, Xi Xi, Xin Zhang, Xitian Zhang, Haoran Zhang, Fei Sun. Lattice complex assembled by noncompetitive anti-EGFR antibodies regulates actin cytoskeletal reorganization. Cancer Cell Int. 2020;20:129. Published 2020 Apr 21. doi:10.1186/s12935-020-01204-z 2020 Apr 21 [26] Yong Yang, Tian Yu, Huan Tang, Zhihui Ren, Qianwen Li, Juan Jia, Hongyu Chen], Jun Fu , Shengchen Ding, Qiang Hao, Dan Xu, Liping Song, Bo Sun, Fei Sun, Jin Pei. Ganoderma lucidum Immune Modulator Protein rLZ-8 Could Prevent and Reverse Bone Loss in Glucocorticoids-Induced Osteoporosis Rat Model. Front Pharmacol. 2020;11:731. 2020 May 19. doi:10.3389/fphar.2020.00731 2020 May 19 [27] Xinhua Lei, Chenyang Zhi, Wei Huang, Xilin Sun, Weiyang Gao, Xue Yin, Xin Zhang, Chongyang Liang, Haoran Zhang, Fei Sun. Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia. Front Pharmacol. 2020;11:956. Published 2020 Jun 26. doi:10.3389/fphar.2020.00956 2020 Jun 26 [28] Xi Xi,Wei han Sun,Hang Su,Xitian Zhang,Fei Sun. Identification of a novel anti-EGFR nanobody by phage display and its distinct paratope and epitope via homology modeling and molecular docking.Molecular Immnunology.2020;128:165-174. 专利 1 具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 孙非、刘立侠、许守民、梁重阳 张喜田 中国 2012.1.4 ZL200810050206.X 2 rlz-8在治疗血小板减少症中的应用及其制剂 孙非、梁重阳、张喜田 张喜田 中国 2012.6.20 ZL200910143424.2 3 重组灵芝免疫调节蛋白单甲氧基聚乙二醇丙酸琥珀酰亚胺酯修饰物、制备方法和用途 孙非、梁重阳、张喜田 张喜田、孙非 中国 2014.3.12 ZL201210243582.7 4 重组灵芝免疫调节蛋白在制备治疗局灶性脑缺血药物中的应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 2014.9.3 ZL201310402259.4 5 重组灵芝免疫调节蛋白与人血清白蛋白融合蛋白及其制备方法与应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 015.1.7 ZL201310479016.0 6 重组灵芝免疫调节蛋白（rlz-8）及其用途 孙非、张喜田 张喜田 澳大利亚 2015.1.15 2008349094 7 重组灵芝免疫调节蛋白（rlz-8）在制备治疗组织纤维化药物中的应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 2015.2.25 ZL201410048713.5 8 重组灵芝免疫调节蛋白（rlz-8）在制备治疗骨质疏松药物中的应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 2015.3.25 ZL201410266772.X 9 重组灵芝免疫调节蛋白单甲氧基聚乙二醇丙酸琥珀酰亚胺脂修饰物、制备方法和用途 孙非、张喜田、梁重阳 张喜田、孙非 台湾 2015.4.1 I478725 10 重组灵芝免疫调节蛋白（rLZ-8）及其用途 日本 2015.4.24 2010-541002 11 重组灵芝免疫调节蛋白（rlz-8）在制备治疗慢性心力衰竭药物中的应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 2015.4.29 ZL201410098980.3 12 重组灵芝免疫调节蛋白(rlz-8)在制备治疗黑色素瘤药物中的应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 2015.6.17 ZL201310357176.8 13 重组灵芝免疫调节蛋白在制备治疗雄激素性脱发药物中的应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 2015.7.1 ZL201410254129.5 14 重组灵芝免疫调节蛋白（rlz-8）在调节血脂中脂蛋白含量的应用 孙非、梁重阳、张喜田 张喜田、孙非 中国 2015.11.11 ZL201410362924.6 15 重组灵芝免疫调节蛋白在制备治疗局灶性脑缺血药物中的应用 梁重阳、张喜田、孙非 张喜田、孙非 英国（欧盟） 2016.6.8 3028712 16 重组灵芝免疫调节蛋白在制备治疗局灶性脑缺血药物中的应用 梁重阳、张喜田、孙非 张喜田、孙非 法国（欧盟） 2016.6.8 3028712 17 重组灵芝免疫调节蛋白在制备治疗白细胞减少症药物中的应用 孙非、刘立侠、许守民、梁重阳 张喜田 中国 2016.9.28 ZL201110222012.5 18 重组灵芝免疫调节蛋白（rLZ-8）及其用途 日本 2016.11.11 2014-245808 19 重组灵芝免疫调节蛋白与人血清白蛋白融合蛋白及其制备方法与应用 张喜田、孙非、梁重阳 孙非、张喜田 澳大利亚 2017.2.23 2014336815 20 重组灵芝免疫调节蛋白在制备治疗局灶性脑缺血药物中的应用 张喜田、孙非 欧盟 2017.5.31 3028712 21 重组灵芝免疫调节蛋白(rlz-8)在制备治疗黑色素瘤药物中的应用 梁重阳 张喜田、孙非 欧盟 2017.9.28 3023104 22 重组灵芝免疫调节蛋白（rLZ-8)在制备治疗组织纤维化药物中的应用 张喜田、孙非、梁重阳 张喜田、孙非 美国 2017.10.17 9789158 23 重组灵芝免疫调节蛋白(rlz-8)在制备治疗黑色素瘤药物中的应用 张喜田、孙非、梁重阳 张喜田、孙非 俄罗斯 2018.3.29 2649129 24 重组灵芝免疫调节蛋白与人血清白蛋白融合蛋白及其制备方法与应用 孙非、张喜田 孙非、张喜田 德国 2015.1.7 3034515 25 重组灵芝免疫调节蛋白与人血清白蛋白融合蛋白及其制备方法与应用 张喜田、孙非、梁重阳 张喜田、孙非 日本 2019.2.8 6475698 26 重组灵芝免疫调节蛋白（rlz-8）及其用途 孙非、张喜田 张喜田 加拿大 2019.10.21 2711207 27 重组灵芝免疫调节蛋白突变体及其应用 孙非、梁重阳 张喜田、孙非 中国 2017.4.8 2020.7.3 CN107118263 B 药物临床试验批准通知书 1. 注射用ZZ-06在EGFR阳性晚期实体瘤患者中的I 期临床评价 受理号：CXSL2000125,通知书编号：2020LP00270。国家药品监督管理局 2. ZZ06(注射用冻干粉) 试验性新药（IND）申请 IND137344 美国食品及药物管理局 |
